Dim app As New MSExcel.Application
try
Dim fileName = "e:\123.xls"
Dim doc As object = App.WorkBooks.Open(fileName)
Dim Ws As MSExcel.WorkSheet = Wb.WorkSheets(1)
For Each a As object In ws.Shapes
a.delete
Next
app.visible = True
catch ex As exception
msgbox(ex.message)
app.Quit
End try